From research lab to dentistry

Saliva testing has been studied in U.S. medicine for decades, but it was the early 2000s that saw its integration into dentistry. Advances in microbiology and DNA testing made it possible to detect the bacteria driving oral disease directly from saliva samples. Today, this non‑invasive approach is helping dental practices move toward faster, more personalized care.

Oral bacteria drive most dental disease

Key bacterial groups linked to gum disease include the Red Complex which contains Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. These pathogens trigger inflammation and tissue destruction that lead to periodontal disease. Other bacteria, such as Streptococcus mutans and Lactobacillus species, cause tooth decay by producing acids that weaken enamel. Detecting these organisms in saliva can reveal active or developing disease well before it is visible in an exam.

Oral pathogens impact overall health

The same bacteria linked to gum disease are associated with systemic conditions such as heart disease, stroke, diabetes, pregnancy complications, and cognitive decline. Chronic oral infections add to the body’s inflammatory burden, increasing the risk and severity of these conditions.

A platform for future disease detection

Human saliva contains over 700 bacterial species along with other biomarkers that can reveal valuable insights into oral and systemic health. This rich source of information makes saliva an ideal foundation for a broader diagnostic platform that extends far beyond dentistry. By starting with real-time, chairside testing for oral disease, your practice can be part of the shift toward earlier detection and prevention of a wide range of health conditions.